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Perry, George

One or more keywords matched the following items that are connected to Perry, George

Item Type	Name
Academic Article	Insights into cerebrovascular complications and Alzheimer disease through the selective loss of GRK2 regulation.
Academic Article	Heme-a, the heme prosthetic group of cytochrome c oxidase, is increased in Alzheimer's disease.
Academic Article	Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta.
Academic Article	Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells.
Academic Article	NMR studies of zinc, copper, and iron binding to histidine, the principal metal ion complexing site of amyloid-beta peptide.
Academic Article	Variably protease-sensitive prionopathy: a new sporadic disease of the prion protein.
Academic Article	Upregulation of presenilin 1 in brains of sporadic, late-onset Alzheimer's disease.
Academic Article	The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies.
Academic Article	Signaling effect of amyloid-beta(42) on the processing of AbetaPP.
Academic Article	Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease.
Academic Article	Cholesterol homeostasis markers are localized to mouse hippocampal pyramidal and granule layers.
Academic Article	Divalent metal transporter, iron, and Parkinson's disease: a pathological relationship.
Academic Article	AGEs/RAGE complex upregulates BACE1 via NF-?B pathway activation.
Academic Article	Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease.
Academic Article	Cellular prion protein is essential for oligomeric amyloid-?-induced neuronal cell death.
Academic Article	Amyloid-? peptide structure in aqueous solution varies with fragment size.
Academic Article	Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover.
Academic Article	Isotyping the human TOMM40 variable-length polymorphism by gene amplification and restriction digest.
Academic Article	The structures of the E22? mutant-type amyloid-? alloforms and the impact of E22? mutation on the structures of the wild-type amyloid-? alloforms.
Academic Article	A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules.
Academic Article	LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1.
Academic Article	Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance.
Academic Article	Phosphorylation of tau protein as the link between oxidative stress, mitochondrial dysfunction, and connectivity failure: implications for Alzheimer's disease.
Academic Article	Proteolytic cleavage of polymeric tau protein by caspase-3: implications for Alzheimer disease.
Academic Article	Islet amyloid polypeptide (IAPP): a second amyloid in Alzheimer's disease.
Academic Article	Curcumin/melatonin hybrid 5-(4-hydroxy-phenyl)-3-oxo-pentanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide ameliorates AD-like pathology in the APP/PS1 mouse model.
Academic Article	A novel SP1/SP3 dependent intronic enhancer governing transcription of the UCP3 gene in brown adipocytes.
Academic Article	Modulation of Parkinson's Disease Associated Protein Rescues Alzheimer's Disease Degeneration.
Academic Article	Identification of Inhibitors of CD36-Amyloid Beta Binding as Potential Agents for Alzheimer's Disease.
Academic Article	Elongation affinity, activation barrier, and stability of A?42 oligomers/fibrils in physiological saline.
Academic Article	1,3-propanediol binds deep inside the channel to inhibit water permeation through aquaporins.
Academic Article	Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein.
Academic Article	Rosmarinic acid prevents fibrillization and diminishes vibrational modes associated to ? sheet in tau protein linked to Alzheimer's disease.
Academic Article	Affinity and path of binding xylopyranose unto E.?coli xylose permease.
Academic Article	Diminished O-GlcNAcylation in Alzheimer's disease is strongly correlated with mitochondrial anomalies.
Academic Article	Analysis of post-translational modifications in Alzheimer's disease by mass spectrometry.
Academic Article	The sterol regulatory element-binding protein 2 is dysregulated by tau alterations in Alzheimer disease.
Academic Article	Consequences of RNA oxidation on protein synthesis rate and fidelity: implications for the pathophysiology of neuropsychiatric disorders.
Academic Article	Incubation with Cu(II) and Zn(II) salts enhances MALDI-TOF mass spectra of amyloid-beta and a-synuclein toward in vivo analysis.
Academic Article	Phosphorylation of Tau protein correlates with changes in hippocampal theta oscillations and reduces hippocampal excitability in Alzheimer's model.
Academic Article	Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases.
Academic Article	Differences in structure and function between human and murine tau.
Academic Article	TDP-43 inhibitory peptide alleviates neurodegeneration and memory loss in an APP transgenic mouse model for Alzheimer's disease.
Academic Article	Predicting the failure of amyloid-beta vaccine.
Academic Article	The neuroprotective activities of melatonin against the Alzheimer beta-protein are not mediated by melatonin membrane receptors.
Academic Article	Senile plaque composition and posttranslational modification of amyloid-beta peptide and associated proteins.
Academic Article	The state versus amyloid-beta: the trial of the most wanted criminal in Alzheimer disease.
Academic Article	Amyloid-beta: a (life) preserver for the brain.
Academic Article	Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice.
Academic Article	Role of high mobility group protein-1 (HMG1) in amyloid-beta homeostasis.
Academic Article	The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
Academic Article	Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease.
Academic Article	Distribution, levels, and activation of MEK1 in Alzheimer's disease.
Academic Article	Cerebrovascular requirement for sealant, anti-coagulant and remodeling molecules that allow for the maintenance of vascular integrity and blood supply.
Academic Article	Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice.
Academic Article	Oxidative stress and neuronal adaptation in Alzheimer disease: the role of SAPK pathways.
Academic Article	Heme catabolism and heme oxygenase in neurodegenerative disease.
Academic Article	Oxidative stress increases expression and activity of BACE in NT2 neurons.
Academic Article	The p38 pathway is activated in Pick disease and progressive supranuclear palsy: a mechanistic link between mitogenic pathways, oxidative stress, and tau.
Academic Article	Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells.
Academic Article	Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence.
Academic Article	JKK1, an upstream activator of JNK/SAPK, is activated in Alzheimer's disease.
Academic Article	Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage.
Academic Article	Possible involvement of Wiskott-Aldrich syndrome protein family in aberrant neuronal sprouting in Alzheimer's disease.
Academic Article	Increased p27, an essential component of cell cycle control, in Alzheimer's disease.
Academic Article	Amyotrophic lateral sclerosis: a novel hypothesis involving a gained 'loss of function' in the JNK/SAPK pathway.
Academic Article	Will preventing protein aggregates live up to its promise as prophylaxis against neurodegenerative diseases?
Academic Article	Tipping the apoptotic balance in Alzheimer's disease: the abortosis concept.
Academic Article	Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition.
Academic Article	Prion protein is ubiquitinated after developing protease resistance in the brains of scrapie-infected mice.
Academic Article	Perspectives on the amyloid-beta cascade hypothesis.
Academic Article	Regulation of glycogen synthase kinase-3beta by products of lipid peroxidation in human neuroblastoma cells.
Academic Article	Concealment of epitope by reduction and alkylation in prion protein.
Academic Article	Mitogen- and stress-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease.
Academic Article	Therapeutic potential of oxidant mechanisms in Alzheimer's disease.
Academic Article	MAPKs are differentially modulated in arctic ground squirrels during hibernation.
Academic Article	Neurotoxic dopamine quinone facilitates the assembly of tau into fibrillar polymers.
Academic Article	P38 activation mediates amyloid-beta cytotoxicity.
Academic Article	Neuropathology in Alzheimer's disease: awaking from a hundred-year-old dream.
Academic Article	Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway?
Academic Article	Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions.
Academic Article	Alzheimer disease, the two-hit hypothesis: an update.
Academic Article	c-Jun phosphorylation in Alzheimer disease.
Academic Article	Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations.
Academic Article	Mitochondria DNA deletions in atherosclerotic hypoperfused brain microvessels as a primary target for the development of Alzheimer's disease.
Academic Article	Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron.
Academic Article	Assembly in vitro of tau protein and its implications in Alzheimer's disease.
Academic Article	Alzheimer's disease: an intracellular movement disorder?
Academic Article	4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal.
Academic Article	Metal ions and oxidative protein modification in neurological disease.
Academic Article	Alpha-synuclein facilitates the toxicity of oxidized catechol metabolites: implications for selective neurodegeneration in Parkinson's disease.
Academic Article	Compensatory responses induced by oxidative stress in Alzheimer disease.
Academic Article	Therapeutic options in Alzheimer's disease.
Academic Article	Amyloid-beta, BACE, and oxidative stress in Alzheimer's disease, a commentary on "The different aggregation state of beta-amyloid 1-42 mediates different effects on oxidative stress, neurodegeneration and BACE-1 expression".
Academic Article	LRRK2 protein is a component of Lewy bodies.
Academic Article	Increased expression of p130 in Alzheimer disease.
Academic Article	Steroidogenic acute regulatory protein (StAR): evidence of gonadotropin-induced steroidogenesis in Alzheimer disease.
Academic Article	Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein.
Academic Article	Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies.
Academic Article	Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer's disease.
Academic Article	Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease.
Academic Article	Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease.
Academic Article	The essential role of ERK in 4-oxo-2-nonenal-mediated cytotoxicity in SH-SY5Y human neuroblastoma cells.
Academic Article	The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha.
Academic Article	Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease.
Academic Article	BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease.
Academic Article	Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.
Academic Article	Neuroprotective effect of cocoa flavonoids on in vitro oxidative stress.
Concept	Serum Amyloid A Protein
Concept	Anion Exchange Protein 1, Erythrocyte
Concept	Glial Fibrillary Acidic Protein
Concept	Protein Binding
Concept	Protein Conformation
Concept	Protein Denaturation
Concept	Protein Kinases
Concept	Protein Precursors
Concept	Protein Processing, Post-Translational
Concept	Protein-Tyrosine Kinases
Concept	Protein Biosynthesis
Concept	Tumor Suppressor Protein p53
Concept	Retinoblastoma Protein
Concept	Amyloid beta-Protein Precursor
Concept	Protein Structure, Secondary
Concept	Protein Structure, Tertiary
Concept	Protein Folding
Concept	MyoD Protein
Concept	Cyclic AMP-Dependent Protein Kinases
Concept	Calcium-Calmodulin-Dependent Protein Kinases
Concept	BRCA1 Protein
Concept	Protein Disulfide-Isomerases
Concept	Mitogen-Activated Protein Kinase 1
Concept	Protein Isoforms
Concept	Mitogen-Activated Protein Kinases
Concept	Mitogen-Activated Protein Kinase Kinases
Concept	Protein Subunits
Concept	Protein Transport
Concept	HMGB1 Protein
Concept	BRCA2 Protein
Concept	Iron Regulatory Protein 1
Concept	Iron Regulatory Protein 2
Concept	Ribosomal Protein S6
Concept	Ribosomal Protein S6 Kinases, 90-kDa
Concept	Receptors, G-Protein-Coupled
Concept	Ubiquitin-Protein Ligases
Concept	JNK Mitogen-Activated Protein Kinases
Concept	p38 Mitogen-Activated Protein Kinases
Concept	Mitogen-Activated Protein Kinase 3
Concept	Mitogen-Activated Protein Kinase 8
Concept	Mitogen-Activated Protein Kinase 9
Concept	Mitogen-Activated Protein Kinase 10
Concept	Retinoblastoma-Like Protein p130
Concept	CREB-Binding Protein
Concept	bcl-2 Homologous Antagonist-Killer Protein
Concept	bcl-X Protein
Concept	bcl-Associated Death Protein
Concept	bcl-2-Associated X Protein
Concept	Wiskott-Aldrich Syndrome Protein Family
Concept	Wiskott-Aldrich Syndrome Protein, Neuronal
Concept	Xeroderma Pigmentosum Group A Protein
Concept	Sterol Regulatory Element Binding Protein 2
Concept	Smad2 Protein
Concept	Amyloid Precursor Protein Secretases
Concept	Protein Phosphatase 2
Concept	Calcium-Calmodulin-Dependent Protein Kinase Type 2
Concept	G-Protein-Coupled Receptor Kinase 2
Concept	Protein Multimerization
Academic Article	?-amyloid 1-42 induces physiological transcriptional regulation of BACE1.
Academic Article	Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links.
Academic Article	PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease.
Academic Article	Towards an Integrative Understanding of tRNA Aminoacylation-Diet-Host-Gut Microbiome Interactions in Neurodegeneration.
Academic Article	Analysis of the Relationship Between Metalloprotease-9 and Tau Protein in Alzheimer's Disease.
Academic Article	Neuroinflammation, hyperphosphorylated tau, diffuse amyloid plaques, and down-regulation of the cellular prion protein in air pollution exposed children and young adults.
Academic Article	Serial reconstruction of beta-protein amyloid plaques: relationship to microvessels and size distribution.
Academic Article	Senile plaques in cerebral amyloid angiopathy show accumulation of amyloid precursor protein without cytoskeletal abnormalities.
Academic Article	Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein.
Academic Article	Immunohistochemical recognition of ethylnitrosourea induced rat brain microtumors by anti-Leu 7 monoclonal antibody.
Academic Article	Age-dependent pattern of intermediate filament protein expression in the human pineal gland.
Academic Article	Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's disease.
Academic Article	Coexistence of cytokeratin, vimentin and neurofilament protein in human choroid plexus. An immunohistochemical study of intermediate filaments in neuroepithelial tissues.
Academic Article	Soluble derivatives of the beta amyloid protein precursor of Alzheimer's disease are labeled by antisera to the beta amyloid protein.
Academic Article	Immunolocalization of the amyloid precursor protein within the senile plaque.
Academic Article	Amyloid precursor protein in senile plaques of Alzheimer disease.
Academic Article	The amyloid percursor protein of Alzheimer disease is expressed as a 130 kDa polypeptide in various cultured cell types.
Academic Article	The glucose transporter of the human brain and blood-brain barrier.
Academic Article	Subcellular localization of amyloid precursor protein in senile plaques of Alzheimer's disease.
Academic Article	Beta protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's disease.
Academic Article	Amyloid precursor protein in cell cultures: a 130 kDa polypeptide.
Academic Article	Ultrastructural localization of erythrocyte cytoskeletal and integral membrane proteins in Plasmodium falciparum-infected erythrocytes.
Academic Article	Hirano bodies contain tau protein.
Academic Article	Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide.
Academic Article	Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease.
Academic Article	Barrier properties of testis microvessels.
Academic Article	Degeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer disease.
Academic Article	The amyloid precursor protein in ischemic brain injury and chronic hypoperfusion.
Academic Article	beta PP and Tau interaction. A possible link between amyloid and neurofibrillary tangles in Alzheimer's disease.
Academic Article	Alterations of low molecular weight acid phosphatase protein level in Alzheimer's disease.
Academic Article	APP transgenesis: approaches toward the development of animal models for Alzheimer disease neuropathology.
Academic Article	Artifactual strain-specific signs of incipient brain amyloidosis in APP transgenic mice.
Academic Article	alpha-calcium-calmodulin-dependent kinase II is associated with paired helical filaments of Alzheimer's disease.
Academic Article	Filament heterogeneity within the dystrophic neurites of senile plaques suggests blockage of fast axonal transport in Alzheimer's disease.
Academic Article	Trypsin interaction with the senile plaques of Alzheimer disease is mediated by beta-protein precursor.
Academic Article	Association of apolipoprotein E with murine amyloid A protein amyloid.
Academic Article	Immunocytochemical evidence that the beta-protein precursor is an integral component of neurofibrillary tangles of Alzheimer's disease.
Academic Article	Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease.
Academic Article	Induction of heme oxygenase-1 mRNA and protein in neocortex and cerebral vessels in Alzheimer's disease.
Academic Article	Alteration of phospholipase C-delta protein level and specific activity in Alzheimer's disease.
Academic Article	Advanced Maillard reaction end products, free radicals, and protein oxidation in Alzheimer's disease.
Academic Article	beta-Amyloid of Alzheimer's disease induces reactive gliosis that inhibits axonal outgrowth.
Academic Article	Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system.
Academic Article	Accumulation of the beta amyloid precursor protein at sites of ischemic injury in rat brain.
Academic Article	Rimmed vacuoles of inclusion body myositis and oculopharyngeal muscular dystrophy contain amyloid precursor protein and lysosomal markers.
Academic Article	Quantitative solubilization and analysis of insoluble paired helical filaments from Alzheimer disease.
Academic Article	Oxidative posttranslational modifications in Alzheimer disease. A possible pathogenic role in the formation of senile plaques and neurofibrillary tangles.
Academic Article	Is amyloid beta-protein glycated in Alzheimer's disease?
Academic Article	Levuglandin E2-protein adducts in human plasma and vasculature.
Academic Article	Alzheimer disease: protein-protein interaction and oxidative stress.
Academic Article	Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo.
Academic Article	Abnormal localization of iron regulatory protein in Alzheimer's disease.
Academic Article	Dimethylargininase, a nitric oxide regulatory protein, in Alzheimer disease.
Academic Article	The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction.
Academic Article	Prion protein glycosylation is sensitive to redox change.
Academic Article	Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease.
Academic Article	Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein.
Academic Article	Protein disulfide isomerase in Alzheimer disease.
Academic Article	Evidence for a novel heme-binding protein, HasAh, in Alzheimer disease.
Academic Article	Induction of NADPH cytochrome P450 reductase by the Alzheimer beta-protein. Amyloid as a "foreign body".
Academic Article	Early glycoxidation damage in brains from Down's syndrome.
Academic Article	Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease.
Academic Article	Is oxidative damage central to the pathogenesis of Alzheimer disease?
Academic Article	A suicide note from Alzheimer disease neurons?
Academic Article	Is increased redox-active iron in Alzheimer disease a failure of the copper-binding protein ceruloplasmin?
Academic Article	Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation.
Academic Article	Overexpression of heme oxygenase in neuronal cells, the possible interaction with Tau.
Academic Article	Prospects for noninvasive imaging of brain amyloid beta in Alzheimer's disease.
Academic Article	Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation.
Academic Article	Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease.
Academic Article	Phosphorylated, but not native, tau protein assembles following reaction with the lipid peroxidation product, 4-hydroxy-2-nonenal.
Academic Article	Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis.
Academic Article	Activation of MKK6, an upstream activator of p38, in Alzheimer's disease.
Academic Article	Neurofilament proteins in neurodegenerative diseases.
Academic Article	Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways.
Academic Article	Retinoic acid isomers protect hippocampal neurons from amyloid-beta induced neurodegeneration.
Academic Article	Synaptic dysfunction and oxidative stress in Alzheimer's disease: emerging mechanisms.
Academic Article	Prospects on the origin of Alzheimer's disease.
Academic Article	Phosphorylation of tau protein at sites Ser(396-404) is one of the earliest events in Alzheimer's disease and Down syndrome.
Academic Article	Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease.
Academic Article	Phospho-Tau Protein Expression in the Cell Cycle of SH-SY5Y Neuroblastoma Cells: A Morphological Study.
Grant	RCMI Center for Interdiscplinary Health Research CIHR
Grant	RCMI Center for Interdiscplinary Health Research CIHR
Grant	AMYLOID PRECURSOR IN ALZHEIMER DISEASE
Grant	NEUROFIBRILLARY PATHOLOGY IN ALZHEIMER DISEASE
Academic Article	Molecular Processing of Tau Protein in Progressive Supranuclear Palsy: Neuronal and Glial Degeneration.
Academic Article	Hypoxic Preconditioning Averts Sporadic Alzheimer's Disease-Like Phenotype in Rats: A Focus on Mitochondria.
Academic Article	MicroRNA networks linked with BRCA1/2, PTEN, and common genes for Alzheimer's disease and breast cancer share highly enriched pathways that may unravel targets for the AD/BC comorbidity treatment.
Academic Article	Evaluation of N- and O-Linked Indole Triazines for a Dual Effect on a-Synuclein and Tau Aggregation.

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